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Screening for Pulmonary Arterial Hypertension in Systemic Sclerosis by Weatherald, Jason; Montani, David; Jevnikar, Mitja; Jaïs, Xavier; Savale, Laurent; Humbert, Marc is a scholarly article available to read on EtoBox.

What is Screening for Pulmonary Arterial Hypertension in Systemic Sclerosis about?

Pulmonary arterial hypertension (PAH) is a dreaded complication of systemic sclerosis (SSc) that occurs in ∼10% of patients. Most individuals present with severe symptoms, significant functional impairment and severe haemodynamics at diagnosis, and survival after PAH diagnosis is poor. Therefore, early diagnosis through systematic screening of asymptomatic patients has the potential to identify PAH at an early stage. Current evidence suggests that early diagnosis and treatment of PAH in patients with SSc may lead to better clinical outcomes. Annual screening may include echocardiography, but this can miss some patients due to suboptimal visualisation or insufficient tricuspid regurgitation. Other options for screening include the DETECT algorithm or the use of a combination of pulmonary function testing (forced vital capacity/diffusing capacity of the lung for carbon monoxide ratio) and N-terminal-pro-brain natriuretic peptide levels. Symptomatic patients, those with an elevated tricuspid regurgitation velocity on echocardiogram with or without secondary echocardiographic features of PAH, and those who screen positive on the DETECT or other pulmonary function test algorithms should

Author

Weatherald, Jason; Montani, David; Jevnikar, Mitja; Jaïs, Xavier; Savale, Laurent; Humbert, Marc

Publisher

European Respiratory Society ; Lausanne: European Respiratory Society; Sheffield: European Respiratory Society; European Respiratory Society (ERS) (ISSN 0905-9180)

Published

2019

Language

EN