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Antimicrobial biosynthetic potential and diversity of culturable soil actinobacteria from forest ecosystems of Northeast India by Sharma, Priyanka; Thakur, Debajit is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Antimicrobial biosynthetic potential and diversity of culturable soil actinobacteria from forest ecosystems of Northeast India about?

Actinobacteria is a goldmine for the discovery of abundant secondary metabolites with diverse biological activities. This study explores antimicrobial biosynthetic potential and diversity of actinobacteria from Pobitora Wildlife Sanctuary and Kaziranga National Park of Assam, India, lying in the Indo-Burma mega-biodiversity hotspot. A total of 107 actinobacteria were isolated, of which 77 exhibited significant antagonistic activity. 24 isolates tested positive for at least one of the polyketide synthase type I, polyketide synthase type II or non-ribosomal peptide synthase genes within their genome. Their secondary metabolite pathway products were predicted to be involved in the production of ansamycin, benzoisochromanequinone, streptogramin using DoBISCUIT database. Molecular identification indicated that these actinobacteria predominantly belonged to genus __Streptomyces__, followed by __Nocardia__ and __Kribbella__. 4 strains, viz. __Streptomyces__ sp. PB-79 (GenBank accession no. KU901725; 1313 bp), __Streptomyces__ sp. Kz-28 (GenBank accession no. KY000534; 1378 bp), __Streptomyces__ sp. Kz-32 (GenBank accession no. KY000536; 1377 bp) and __Streptomyces__ sp. Kz-67 (GenBank acc

Who reads Antimicrobial biosynthetic potential and diversity of culturable soil actinobacteria from forest ecosystems of Northeast India?

Author

Sharma, Priyanka; Thakur, Debajit

Publisher

Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)