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Cavitas electrochemical sensor toward detection of N-epsilon (carboxymethyl)lysine in oral cavity by Bianca Ciui; Mihaela Tertis; Claudia N. Feurdean; Aranka Ilea; Robert Sandulescu; Joseph Wang; Cecilia Cristea is a Engineering article available to read on EtoBox.

What is Cavitas electrochemical sensor toward detection of N-epsilon (carboxymethyl)lysine in oral cavity about?

Advanced glycated end products N € (carboxymethyl)lysine Differential pulse voltammetry A B S T R A C T Advanced glycated end markers are involved in oxidative stress by producing long-term damage to proteins in ageing processes, atherosclerosis, and diabetes. The present work describes a cavitas printed electrochemical sensor for the direct salivary detection of N € (Carboxymethyl)lysine, a major advanced glycated end compound. The highly flexible and bendable sensor is integrated on a customized mouthguard placed on a phantom jaw that imitated the structure of the human oral cavity. The disposable sensor is readily attached on the mouthguard before usage and detached after the electrochemical investigation. Thus, it can be replaced whenever required. The sensor exhibits high selectivity and sensitivity in the phosphate buffer with a limit of detection of 166 ng/ml (equivalent to 0.81 μM) (over a range of 0.5-2500 μg/ml (equivalent to 2.45 μM-12.24 mM) N € (Carboxymethyl) lysine by employing a differential pulse voltammetry analytical procedure. Moreover, the cavitas sensor was tested in raw, untreated human saliva, and promising recoveries were obtained. The cost advantages of th

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Author

Bianca Ciui; Mihaela Tertis; Claudia N. Feurdean; Aranka Ilea; Robert Sandulescu; Joseph Wang; Cecilia Cristea

Publisher

Elsevier BV

Published

2019

Language

EN

Field

Engineering (Physical Sciences)