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Can I read Nanog Expression in Embryonic Stem Cells – An Ideal Model System to Dissect Enhancer Function on EtoBox?
Nanog Expression in Embryonic Stem Cells – An Ideal Model System to Dissect Enhancer Function by Steven Blinka; Sridhar Rao is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Nanog Expression in Embryonic Stem Cells – An Ideal Model System to Dissect Enhancer Function about?
Embryonic stem cells (ESCs) are derived from the preimplantation embryo and can differentiate into virtually any other cell type (termed pluripotency), which is governed by lineage specific transcriptions factors (TFs) binding to __cis__ regulatory elements (CREs) to mediate changes in gene expression. The reliance on transcriptional regulation to maintain pluripotency makes ESCs a valuable model to study the role of distal CREs such as enhancers in modulating gene expression to affect cell fate decisions. This review will highlight recent advance on transcriptional enhancers, focusing on studies performed in ESCs. In addition, we argue that the __Nanog__ locus, which encodes for an ESC‐critical TF, is particularly informative because it contains multiple co‐regulated genes and enhancers in close proximity to one another. The unique landscape at __Nanog__ permits the study of ongoing questions including whether multiple enhancers function additively versus synergistically, determinants of gene specificity, and cell‐to‐cell variability in gene expression.
Who reads Nanog Expression in Embryonic Stem Cells – An Ideal Model System to Dissect Enhancer Function?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Steven Blinka; Sridhar Rao
- Publisher
- Wiley
- Published
- 2017
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)