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Avermectin B1 Safety in Veterinary Use by Bozica Solomun Kolanovic is a document available to read on EtoBox.

This document summarizes toxicological data on the veterinary drug doramectin. It is in the avermectin class of compounds and is used as an endoparasitic agent in non-lactating cattle. Studies in collie dogs and Murray Grey cattle showed they are more sensitive than other species to the toxicity of avermectins. Doramectin was previously evaluated by JECFA and an ADI of 0-0.5 mg/kg bw was established based on a NOEL in dogs and using safety factors. Polymorphisms in the human MDR1 gene may affect sensitivity

Author

Bozica Solomun Kolanovic

Language

EN