About this Chemistry article
Silver Nanoparticles Loaded on Chitosan-g-PVA Hydrogel for the Wound-Healing Applications by Fahad M. Aldakheel; Dalia Mohsen; Marwa M. El Sayed; Khaled Ali Alawam; AbdulKarim S. Binshaya; Shatha A. Alduraywish is a Chemistry article available to read on EtoBox.
Silver nanoparticle composites have abundant biomedical applications due to their unique antibacterial properties. In the current work, green tea leaf extract was used as a natural reducing agent to synthesize AgNPs (AgNPs) using microwave irradiation technology. Furthermore, microwave irradiation has been used for the preparation of AgNPs/chitosan (Ch) grafted polyvinyl alcohol (PVA) hydrogel samples. To approve the accomplishment of AgNPs hydrogel polymer, UV-spectrum, TEM, and FT-IR spectrum analyses and the release of silver ions, actions were taken. The wound-healing ability of the prepared hydrogel samples was measured via both the in vitro (fibroblast cells) and the in vivo using rat models. It was found that chitosan-grafted polyvinyl alcohol, including AgNPs, exhibited excellent antibacterial activity against __E. coli__ and __S. aureus__ using the agar diffusion method. It can be said that microwave irradiation was successful in creating a hydrogel that contained silver nanoparticles. A wound that was still open was successfully treated with these composites.
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- Author
- Fahad M. Aldakheel; Dalia Mohsen; Marwa M. El Sayed; Khaled Ali Alawam; AbdulKarim S. Binshaya; Shatha A. Alduraywish
- Publisher
- MDPI AG
- Published
- 2023
- Language
- EN
- Field
- Chemistry (Life Sciences)