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Can I read The REPAIR Study: Effects of Macitentan on RV Structure and Function in Pulmonary Arterial Hypertension on EtoBox?
The REPAIR Study: Effects of Macitentan on RV Structure and Function in Pulmonary Arterial Hypertension by Anton Vonk Noordegraaf; Richard Channick; Emmanuelle Cottreel; David G. Kiely; J. Tim Marcus; Nicolas Martin; Olga Moiseeva; Andrew Peacock; Andrew J. Swift; Ahmed Tawakol; Adam Torbicki; Stephan Rosenkranz; Nazzareno Galiè is a Medicine article available to read on EtoBox.
What is The REPAIR Study: Effects of Macitentan on RV Structure and Function in Pulmonary Arterial Hypertension about?
## Objectives: The repair (right ventricular remodeling in pulmonary arterial hypertension) study evaluated the effect of macitentan on right ventricular (rv) and hemodynamic outcomes in patients with pulmonary arterial hypertension (pah), using cardiac magnetic resonance (cmr) and right heart catheterization (rhc). ## Background: Rv failure is the primary cause of death in pah. cmr is regarded as the most accurate noninvasive method for assessing rv function and remodeling and cmr measures of rv function and structure are strongly prognostic for survival in patients with pah. despite this, cmr is not routinely used in pah clinical trials. ## Methods: Repair was a 52-week, open-label, single-arm, multicenter, phase 4 study evaluating the effect of macitentan 10 mg, with or without phosphodiesterase type-5 inhibition, on rv remodeling and function and cardiopulmonary hemodynamics. primary endpoints were change from baseline to week 26 in rv stroke volume, determined by cmr; and pulmonary vascular resistance, determined by rhc. efficacy measures were assessed for all patients with baseline and week 26 data for both primary endpoints. ## Results: At a prespecified interim analysis in
Who reads The REPAIR Study: Effects of Macitentan on RV Structure and Function in Pulmonary Arterial Hypertension?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Anton Vonk Noordegraaf; Richard Channick; Emmanuelle Cottreel; David G. Kiely; J. Tim Marcus; Nicolas Martin; Olga Moiseeva; Andrew Peacock; Andrew J. Swift; Ahmed Tawakol; Adam Torbicki; Stephan Rosenkranz; Nazzareno Galiè
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)