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Peripapillary Atrophy Area as an Indicator of Glaucomatous Structural and Functional Progression by Khreish, Maroun (author);Schuman, Joel S. (author);Lee, TingFang (author);Ghassabi, Zeinab (author);Zambrano, Ronald (author);Hu, Jiyuan (author);Ishikawa, Hiroshi (author);Wollstein, Gadi (author);Lavinsky, Fabio (author) is a Medicine article available to read on EtoBox.

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## Purpose To determine whether peripapillary atrophy (PPA) area is an indicator of glaucomatous structural and functional damage and progression. ## Methods In this retrospective longitudinal analysis from ongoing prospective study we qualified 71 eyes (50 subjects) with glaucoma. All subjects had a comprehensive ophthalmic examination, visual field (VF), and spectral-domain optical coherence tomography (OCT) testing in at least three visits. PPA was manually delineated on en face OCT optic nerve head scans, while observing the corresponding cross-sectional images, as the hyper-reflective area contiguous with the optic disc. ## Results The mean follow-up duration was 4.4 ± 1.4 years with an average of 6.8 ± 2.2 visits. At baseline, PPA area was significantly associated only with VF's mean deviation (MD; __P__ = 0.041), visual field index (VFI; __P__ = 0.041), superior ganglion cell inner plexiform layer (GCIPL; __P__ = 0.011), and disc area (__P__ = 0.011). Longitudinally, PPA area was negatively and significantly associated with MD (__P__ = 0.015), VFI (__P__ = 0.035), GCIPL (__P__ = 0.009), superior GCIPL (__P__ = 0.034), and disc area (__P__ = 0.007, positive association). ## C

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Author

Khreish, Maroun (author);Schuman, Joel S. (author);Lee, TingFang (author);Ghassabi, Zeinab (author);Zambrano, Ronald (author);Hu, Jiyuan (author);Ishikawa, Hiroshi (author);Wollstein, Gadi (author);Lavinsky, Fabio (author)

Publisher

Association for Research in Vision and Ophthalmology (ARVO)

Published

2024

Language

EN

Field

Medicine (Health Sciences)