Can I read Serum Pseudocholinesterase and Very-low-density Lipoprotein Metabolism on EtoBox?
Serum Pseudocholinesterase and Very-low-density Lipoprotein Metabolism by Dr. K. M. Kutty; R. H. Payne is a Medicine article available to read on EtoBox.
What is Serum Pseudocholinesterase and Very-low-density Lipoprotein Metabolism about?
Serum pseudocholinesterase (PChE) was discovered in 1932. Since this protein mimics many of the catalytic properties of acetylcholinesterase, it has traditionally been referred to as PChE, even though its true biological function is unknown. Serum PChE is synthesized in the liver and secreted into the circulation as a sialated glycoprotein. Although no convincing evidence of biological function exists, a significant number of obese and diabetic patients have elevated levels of PChE. The same phenomenon is found in experimental animal models of obesity, diabetes and hyperlipoproteinemia. Streptozotocin-induced diabetic mice showed increased serum PChE activity concomitant with increased serum triacylglycerol and PChE activity declined with treatment. Iso-OMPA, a nontoxic inhibitor of serum PChE, reduced serum and liver triacylglycerols and serum VLDL in streptozotocininduced rodent diabetes. These findings suggest that PChE may have a role in VLDL metabolism. Q 19% Wiley-Liss, Inc.
Who reads Serum Pseudocholinesterase and Very-low-density Lipoprotein Metabolism?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dr. K. M. Kutty; R. H. Payne
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-8013)
- Published
- 1994
- Language
- EN
- Field
- Medicine (Health Sciences)