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Can I read Clodronate Inhibits Angiogenesis in Vitro and in Vivo on EtoBox?
Clodronate Inhibits Angiogenesis in Vitro and in Vivo by Ribatti, D.; Maruotti, N.; Nico, B.; Longo, V.; Mangieri, D.; Vacca, A.; Cantatore, F. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Clodronate Inhibits Angiogenesis in Vitro and in Vivo about?
The effects of amino-bisphosphonate clodronate on endothelial cell functions involved in angiogenesis, namely proliferation and morphogenesis on matrigel were tested in vitro, whereas its effects on angiogenesis were studied in vivo. This was performed by using the chick embryo chorioallantoic membrane (CAM) assay. In vitro, clodronate inhibited the endothelial cell proliferation in a dose-dependent fashion, peaking at 30 μM. At the same concentration, clodronate inhibited the fibroblast growth factor-2 (FGF-2)induced capillary-like tube formation in the morphogenesis assay on matrigel. In vivo, when tested with the CAM assay, clodronate again displayed the capability to inhibit FGF-2induced angiogenesis. Overall, these results suggest that antiangiogenesis by clodronate can be used to treat a wide spectrum of angiogenesis-dependent diseases, including certain chronic inflammatory diseases and cancer.
Who reads Clodronate Inhibits Angiogenesis in Vitro and in Vivo?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ribatti, D.; Maruotti, N.; Nico, B.; Longo, V.; Mangieri, D.; Vacca, A.; Cantatore, F.
- Publisher
- Spandidos Publications Ltd; Spandidos Publications; Demetrios A. Spandidos Ed. & Pub. (ISSN 1021-335X)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)