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Use of H19 regulatory sequences for targeted gene therapy in cancer by Patricia Ohana; Osaat Bibi; Imad Matouk; Carol Levy; Tatiana Birman; Ilana Ariel; Tamar Schneider; Suhail Ayesh; Hilla Giladi; Morris Laster; Nathan de Groot; Abraham Hochberg is a Medicine article available to read on EtoBox.
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## Abstract We present a tumor gene therapy approach based on the use of regulatory sequences of the H19 gene that are differentially expressed between normal and cancer cells. We constructed expression vectors carrying the gene for the A fragment of diphtheria toxin (DT‐A) or herpes simplex virus thymidine kinase (HSV‐__tk__), under the control of a 814 bp 5′‐flanking region of the __H19__ gene. The cell killing activity of these constructs was in accordance with the relative activity of the H19 regulatory sequences in the transfected cells. We evaluated the therapeutic potential of the gene expression constructs driven by H19 regulatory sequences in an animal model of bladder cancer induced by subcutaneous injection of syngeneic bladder tumor cell lines. Intratumoral injection of these constructs caused a significant suppression of subcutaneous tumor growth, with no obvious toxicity toward the host. © 2002 Wiley‐Liss, Inc.
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- Author
- Patricia Ohana; Osaat Bibi; Imad Matouk; Carol Levy; Tatiana Birman; Ilana Ariel; Tamar Schneider; Suhail Ayesh; Hilla Giladi; Morris Laster; Nathan de Groot; Abraham Hochberg
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)