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Can I read Alterations in effort-related decision-making induced by stimulation of dopamine D1, D2, D3, and corticotropin-releasing factor receptors in nucleus accumbens subregions on EtoBox?
Alterations in effort-related decision-making induced by stimulation of dopamine D1, D2, D3, and corticotropin-releasing factor receptors in nucleus accumbens subregions by Courtney A. Bryce; Stan B. Floresco is a Neuroscience article available to read on EtoBox.
What is Alterations in effort-related decision-making induced by stimulation of dopamine D1, D2, D3, and corticotropin-releasing factor receptors in nucleus accumbens subregions about?
Rationale Nucleus accumbens (NAc) dopamine (DA) plays an integral role in overcoming effort costs, as blockade of D 1 and D 2 receptors reduces the choice of larger, more-costly rewards. Similarly, the stress neuropeptide corticotropin-releasing factor (CRF) modulates DA transmission and mediates stress-induced alterations in effort-related choice. Objectives The current study explored how excessive stimulation of different DA receptors within the NAc core and shell alters effort-related decision-making and compared these effects to those induced by CRF stimulation. Methods Male Long Evans rats were well-trained on an effort-discounting task wherein they choose between a low-effort/lowreward and a high-effort/high-reward lever where the effort requirement increased over blocks (2-20 presses). Dopamine D 1 (SKF 81297, 0.2-2 μg), D 2/3 (quinpirole, 1-10 μg), or D 3 (PD 128,907, 1.5-3 μg) receptor agonists, or CRF (0.5 μg), were infused into the NAc core or shell prior to testing. Results Stimulation of D 2/3 receptors with quinpirole in the NAc core or shell markedly reduced the choice of high-effort option and increase choice latencies, without altering preference for larger vs smal
Who reads Alterations in effort-related decision-making induced by stimulation of dopamine D1, D2, D3, and corticotropin-releasing factor receptors in nucleus accumbens subregions?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Courtney A. Bryce; Stan B. Floresco
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0033-3158)
- Published
- 2019
- Language
- EN
- Field
- Neuroscience (Life Sciences)