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Adult Rat Morphine Exposure Changes Morphine Preference, Anxiety, and the Brain Expression of Dopamine Receptors in Male Offspring by Nasim Vousooghi; Mitra‐Sadat Sadat‐Shirazi; Payam Safavi; Ramin Zeraati; Ardeshir Akbarabadi; Seyed Mohammad Makki; Shahrzad Nazari; Mohammad Reza Zarrindast is a Neuroscience article available to read on EtoBox.
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## Abstract Addiction to drugs, including opioids is the result of an interplay between environmental and genetic factors. It has been shown that the progeny of addict people is at higher risk for drug addiction. However, the mechanisms of such trans‐generational effects of drugs are not so clear. Here we have evaluated the effects of parental morphine consumption on anxiety, morphine preference, and mRNA expression of dopamine receptors in F1 and F2 male offspring. Morphine was chronically administered to adult male and female Wistar rats followed by 14‐day abstinence before mating. Morphine preference and anxiety‐like behavior in the offspring were measured by two‐bottle‐choice paradigm and elevated‐plus maze, respectively. Real‐time PCR was used to measure the mRNA expression level of dopamine receptors in the striatum, nucleus accumbens, prefrontal cortex, and hippocampus of F1 animals. The results indicated that F1 but not the F2 male progeny of morphine‐exposed parents had a greater preference for morphine, and more anxiety‐like behavior compared to the offspring of saline‐treated parents. In F1 male progeny of morphine‐treated parents, D1 and D5 dopamine receptors were signi
Who reads Adult Rat Morphine Exposure Changes Morphine Preference, Anxiety, and the Brain Expression of Dopamine Receptors in Male Offspring?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Nasim Vousooghi; Mitra‐Sadat Sadat‐Shirazi; Payam Safavi; Ramin Zeraati; Ardeshir Akbarabadi; Seyed Mohammad Makki; Shahrzad Nazari; Mohammad Reza Zarrindast
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Wiley; Elsevier BV (ISSN 0736-5748)
- Published
- 2018
- Language
- EN
- Field
- Neuroscience (Life Sciences)