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Safety and Efficacy of Coma Induction Following First-Line Treatment in Status Epilepticus: A 2-Center Study by Pia De Stefano; Sira Maria Baumann; Saskia Semmlack; Stephan Rüegg; Stephan Marsch; Margitta Seeck; Raoul Sutter is a Medicine article available to read on EtoBox.
What is Safety and Efficacy of Coma Induction Following First-Line Treatment in Status Epilepticus: A 2-Center Study about?
## Objective To explore the safety and efficacy of artificial coma induction to treat status epilepticus (SE) immediately after first-line antiseizure treatment instead of following the recommended approach of first using second-line drugs. ## Methods Clinical and electrophysiologic data of all adult patients treated for SE from 2017 to 2018 in the Swiss academic medical care centers from Basel and Geneva were retrospectively assessed. Primary outcomes were return to premorbid neurologic function and in-hospital death. Secondary outcomes were the emergence of complications during SE, duration of SE, and intensive care unit (ICU) and hospital stays. ## Results Of 230 patients, 205 received treatment escalation after first-line medication. Of those, 27.3% were directly treated with artificial coma and 72.7% with second-line nonanesthetic antiseizure drugs. Of the latter, 16.6% were subsequently put on artificial coma after failure of second-line treatment. Multivariable analyses revealed increasing odds for coma induction after first-line treatment with younger age, the presence of convulsions, and an increased SE severity as quantified by the Status Epilepticus Severity Score (STESS
Who reads Safety and Efficacy of Coma Induction Following First-Line Treatment in Status Epilepticus: A 2-Center Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Pia De Stefano; Sira Maria Baumann; Saskia Semmlack; Stephan Rüegg; Stephan Marsch; Margitta Seeck; Raoul Sutter
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)