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What is p16 Loss in Esophageal Adenocarcinoma about?

1) The study assessed expression of the tumor suppressor protein p16 in 13 patients with esophageal adenocarcinoma (EAC) using immunohistochemistry and fluorescence in situ hybridization (FISH). 2) Loss of p16 protein expression was detected in 77% of cases by immunohistochemistry. Loss of the p16 gene was found in 69% of cases by FISH, with hemizygous deletion being most common. 3) A significant correlation was found between absence of p16 protein expression and loss of the p16 gene, suggesting that p16

Author
Teodor
Language
EN