About this Medicine article
Hyperthermia induces T1 relaxation and blood flow changes in tumors. A MRI thermometry study in vivo by Michael Peller; Volker Kurze; Ralf Loeffler; Sascha Pahernik; Marc Dellian; Alwin E Goetz; Rolf Issels; Maximilian Reiser is a Medicine article available to read on EtoBox.
Regional hyperthermia in combination with chemotherapy and/or radiotherapy has proven to be an effective treatment concept for locally advanced deep-seated tumors. Simultaneous MR-imaging could be a promising approach for therapy optimization. Purpose of this study was the in vivo investigation of temperature induced longitudinal relaxation time (T(1)) and blood flow changes in a tumor model. Using a 1.5 Tesla MR system, the T(1) sensitivity on temperature and the onset of tissue changes at temperatures >44 degrees C were investigated in muscle samples. Also, fourteen Syrian Golden Hamsters with amelanotic melanoma A-MEL-3 were examined during heating of the tumors. Temperature induced blood flow and T(1) changes were determined continuously during hyperthermia. Changes of T(1) correlated linearly with temperature over a wide range (27-44 degrees C) in the tissue sample. Tissue changes became notable above 44 degrees C. In the tumor model, relative changes of T(1) (unlike blood flow) showed linear correlation with temperature over the entire range of hyperthermia relevant temperatures (32-44 degrees C). For a low thermal dose, T(1) allows the assessment of temperature changes in tu
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- Author
- Michael Peller; Volker Kurze; Ralf Loeffler; Sascha Pahernik; Marc Dellian; Alwin E Goetz; Rolf Issels; Maximilian Reiser
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0730-725X)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)