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Thrombocytopenia in the Experimental Leptospirosis of Guinea Pig Is Not Related to Disseminated Intravascular Coagulation by Hong-Liang Yang; Xu-Cheng Jiang; Xiang-Yan Zhang; Wen-Jun LI; Bao-Yu HU; Guo-Ping Zhao; Xiao-Kui Guo is a Medicine article available to read on EtoBox.
What is Thrombocytopenia in the Experimental Leptospirosis of Guinea Pig Is Not Related to Disseminated Intravascular Coagulation about?
## Background Thrombocytopenia is commonly observed in severe leptospirosis. However, previous studies on coagulation alterations during leptospirosis resulted in inconsistent conclusions. Some findings showed that the prominent levels of thrombocytopenia observed in severe leptospirosis did not reflect the occurrence of disseminated intravascular coagulation (DIC) syndrome, while the others reached the conclusion that the hemorrhages observed in leptospirosis were due to DIC. The aim of this study is to elucidate whether DIC is an important feature of leptospirosis. ## Methods The leptospirosis model of guinea pig was established by intraperitoneal inoculation of __Leptospira interrogans__ strain Lai. Hematoxylin and eosin (HE) staining, electron microscopy and immunohistochemistry staining were used to detect the pathologic changes. Platelet thrombus or fibrin thrombus was detected by HE, Martius Scarlet Blue (MSB) staining and electron microscopy. Hemostatic molecular markers such as 11-dehydrogenate thromboxane B2 (11-DH-TXB2), thrombomodulin (TM), thrombin-antithrombin III complex (TAT), D-Dimer and fibrin (ogen) degradation products (FDPs) in the plasma were examined by quant
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- Author
- Hong-Liang Yang; Xu-Cheng Jiang; Xiang-Yan Zhang; Wen-Jun LI; Bao-Yu HU; Guo-Ping Zhao; Xiao-Kui Guo
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2334)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)