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Septic shock: Past, present, and perspectives by Erika P. Plata-Menchaca is a book available to read on EtoBox.

What is Septic shock: Past, present, and perspectives about?

Journal of Critical Care, 91 (2026) 155269. doi:10.1016/j.jcrc.2025.155269Septic shock remains one of the most severe complications of infection, defined by circulatory, cellular, and metabolic dysfunction and associated with persistently high mortality. The concept has evolved markedly, from early descriptions of “blood poisoning” to the recognition of sepsis as a systemic syndrome in the late 20th century. Consensus definitions and large clinical trials, including early goal-directed therapy, led to structured treatment bundles and the launch of the Surviving Sepsis Campaign, which have contributed to gradual improvements in survival.Current management emphasizes rapid recognition, timely antimicrobials, source control, fluid resuscitation, Artificial intelligenceand vasopressor support, with norepinephrine as the first-line agent. Nevertheless, significant heterogeneity among patients complicates decision-making, and debate continues around fluid thresholds, timing of vasopressor initiation, and the use of adjunctive therapies such as corticosteroids or immunomodulators.Looking ahead, precision medicine and emerging technologies promise to refine sepsis care. Machine learning

Author

Erika P. Plata-Menchaca

Publisher

×

Published

2025

Language

EN