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Cell Cycle Regulation of Thymidylate Synthetase Gene Expression in Cultured Mouse Fibroblasts. by L.G. Navalgund; C. Rossana; A.J. Muench; L.F. Johnson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Cell Cycle Regulation of Thymidylate Synthetase Gene Expression in Cultured Mouse Fibroblasts. about?
This study describes the regulation of thymidylate synthetase activity in mouse 3T6 fibroblasts during serum-induced transitions between the resting (Go) and growing state. The specific activity of thymidylate synthetase was about 17 times lower in resting 3T6 cells than in exponentially growing cells. When resting cells were serum-stimulated to re-enter the cell cycle, thymidylate synthetase activity remained at the level found in resting cells until 12 h following stimulation (GO-GI phase), then increased sharply as the cells entered S phase. Enzyme activity increased about 20-fold over that of resting cells by 30 h following stimulation and continued to increase linearly for at least another 30 h. Studies with inhibitors of protein and RNA syn-
Who reads Cell Cycle Regulation of Thymidylate Synthetase Gene Expression in Cultured Mouse Fibroblasts.?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- L.G. Navalgund; C. Rossana; A.J. Muench; L.F. Johnson
- Publisher
- Elsevier BV
- Published
- 1980
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)