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Saw Palmetto Is an Indirectly Acting Sympathomimetic in the Rat-isolated Prostate Gland by Nga Cao; John M. Haynes; Sabatino Ventura is a Medicine article available to read on EtoBox.

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## Background: To investigate whether saw palmetto that inhibits alpha1-adrenoceptor binding in vitro affects contractility of the rat prostate gland. ## Methods: The effects of a commercially available saw palmetto extract were examined on the contractility of rat-isolated prostate glands. the extract was tested in the presence and absence of phentolamine, prazosin, yohimbine, propranolol, hexamethonium, cocaine, desipramine, nifedipine, guanethidine, atropine, and alpha,beta-methylene atp to evaluate the mechanism of action. isolated preparations of rat vas deferens and bladder were used for comparison. ## Results: Unexpectedly, saw palmetto extract caused contractions of the rat prostate gland that could be attenuated by prazosin, phentolamine, nifedipine, guanethidine, cocaine, and desipramine but not by any of the other pharmacological tools. similar contractile effects were observed in rat-isolated vas deferens preparations but not in rat-isolated bladder preparations. ## Conclusions: In the rat prostate gland, saw palmetto extract causes indirect alpha1-adrenoceptor-mediated contractions via the release of noradrenaline from sympathetic neurons.

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Author

Nga Cao; John M. Haynes; Sabatino Ventura

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2006

Language

EN

Field

Medicine (Health Sciences)