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Left-bundle Branch Block, an Alert for Cardiac Resynchronization Therapy by P Gatti; I Kristjansdottir; A Azari; M Anselmino; S Lind; G Savarese; C Linde; F Gadler is a scholarly article available to read on EtoBox.

What is Left-bundle Branch Block, an Alert for Cardiac Resynchronization Therapy about?

## Abstract ## Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Medtronic. ## Background Left bundle branch block (LBBB) might be the first finding of cardiovascular diseases but it is also the target of cardiac resynchronization therapy (CRT) in heart failure (HF) with reduced ejection fraction (HFrEF). LBBB prognosis and the implication of CRT in an unselected real-world setting are of great potential clinical impact. ## Methods A central ECG database together with national registries has been screened to identify LBBB patients. Cox models were fitted to assess the hazard ratio (HR) of death, cardiovascular death (CVD) and HF hospitalization (HFH) according to gender and CRT use. A subdistribution of the hazard ratio (SHR) was used to account for non-cardiovascular death as a competing risk. Logistic regression was fitted to investigate characteristics associated with CRT use. ## Results Of 5359 patients with LBBB and QRS duration over 150ms, 36% were female. The median age was 76 years and males had a significantly higher risk of death after 5 years from the LBBB diagnosis. CRT, when indicated, has a large benefit on all-causes of death

Author

P Gatti; I Kristjansdottir; A Azari; M Anselmino; S Lind; G Savarese; C Linde; F Gadler

Publisher

Oxford University Press (OUP)

Published

2023

Language

EN