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Can I read Casposons: mobile genetic elements that gave rise to the CRISPR-Cas adaptation machinery on EtoBox?
Casposons: mobile genetic elements that gave rise to the CRISPR-Cas adaptation machinery by Mart Krupovic; Pierre Béguin; Eugene V Koonin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Casposons: mobile genetic elements that gave rise to the CRISPR-Cas adaptation machinery about?
A casposon, a member of a distinct superfamily of archaeal and bacterial self-synthesizing transposons that employ a recombinase (casposase) homologous to the Cas1 endonuclease, appears to have given rise to the adaptation module of CRISPR-Cas systems as well as the CRISPR repeats themselves. Comparison of the mechanistic features of the reactions catalyzed by the casposase and the Cas1-Cas2 heterohexamer, the CRISPR integrase, reveals close similarity but also important differences that explain the requirement of Cas2 for integration of short DNA fragments, the CRISPR spacers.
Who reads Casposons: mobile genetic elements that gave rise to the CRISPR-Cas adaptation machinery?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Mart Krupovic; Pierre Béguin; Eugene V Koonin
- Publisher
- Elsevier BV
- Published
- 2017
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)
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