Can I read Demographics, socio‐behavioral factors, and drug use patterns: What matters in spontaneous HCV clearance? on EtoBox?

Demographics, socio‐behavioral factors, and drug use patterns: What matters in spontaneous HCV clearance? by Dimpy P. Shah; Carolyn Z. Grimes; Eric Brown; Lu‐Yu Hwang is a Medicine article available to read on EtoBox.

What is Demographics, socio‐behavioral factors, and drug use patterns: What matters in spontaneous HCV clearance? about?

## Abstract Hepatitis C virus (HCV), an emerging bloodborne pathogen, causes chronic liver disease frequently except in about 10–20% of infections which undergo spontaneous resolution. Investigating factors that influence viral clearance is essential to understand the natural history of this infection and establishing novel strategies for prevention and treatment. HCV clearance was estimated in a unique cohort of 1,260 HIV and HBV negative current drug users enrolled for a hepatitis B vaccination study. It was defined as the inability to detect viral RNA using a PCR method in presence of serum anti‐HCV antibody EIA. Associated demographic and socio‐behavioral factors including drug use patterns were identified from the enrolled subjects using multivariate regression analysis. 33.3% (420/1260) of drug users were found positive for anti‐HCV antibodies and 14.8% (62/420) of these individuals achieved viral clearance (negative PCR test). Race or ethnicity of the participants was the only significant factor associated with HCV clearance. Hispanics (OR = 3.4, 95% CI: 1.3–8.5, __P__ = 0.01) and Caucasians (OR = 3.1, 95% CI: 1.5–6.6, __P__ = 0.003) had significantly higher odds of clearing

Who reads Demographics, socio‐behavioral factors, and drug use patterns: What matters in spontaneous HCV clearance??

Author

Dimpy P. Shah; Carolyn Z. Grimes; Eric Brown; Lu‐Yu Hwang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

2011

Language

EN

Field

Medicine (Health Sciences)