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The Palau early psychosis study: Distribution of cases by level of genetic risk by Marina Myles-Worsley; Francisca Blailes; Lisa M. Ord; Starla Weaver; Gregory Dever; Stephen V. Faraone is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The Palau Early Psychosis Study (PEPS) was designed to examine the pathogenesis of early psychosis in a high‐risk population isolate. This paper describes the characteristics of our community‐based, non‐help seeking sample of 404 Palauan adolescents and quantifies the presence of early psychosis by level of genetic risk. The sample included 53 offspring of a schizophrenic parent designated as “Genetically Highest Risk” (GHR+) and 68 nieces/nephews of sib‐pairs/trios, designated as “Genetically High Risk” (GHR). The remaining subjects were recruited through a high school survey that identified 62 “Genetically Moderate Risk” (GMR) adolescents with an affected second or third degree relative and 221 “Genetically Low Risk” (GLR) subjects with no close affected relatives. The GLR adolescents included 117 symptomatic or “Clinically High Risk” (CHR) adolescents and 104 asymptomatic normal controls. Based on a modified K‐SADS‐PL assessment, we identified 221 adolescents with early psychosis, 62 or 28% of whom had already transitioned to a psychotic disorder. Together, the two highest risk groups contributed 31% of the adolescent‐onset psychosis cases and 27% of the prodromals.

Who reads The Palau early psychosis study: Distribution of cases by level of genetic risk?

Author

Marina Myles-Worsley; Francisca Blailes; Lisa M. Ord; Starla Weaver; Gregory Dever; Stephen V. Faraone

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1552-4841)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)