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Effect of T-cell receptor V?-specific monoclonal antibodies on cyclophosphamide-induced diabetes mellitus in non-obese diabetic mice by T. Taki; K. Yokono; K. Amano; N. Hatamori; Y. Hirao; Y. Tominaga; S. Maeda; M. Kasuga is a Medicine article available to read on EtoBox.

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The expression of specific T-cell receptor gene segments by T lymphocytes appears to be critically important for the induction of several experimental autoimmune diseases mediated by these cells. We examined whether this situation also applied to non-obese diabetic mice by using various T-cell receptor Vfl-specific monoclonal antibodies. No significant age-or sex-related differences were observed in Vfl usage by peripheral and splenic T lymphocytes. CD8 + T lymphocytes among the islet-derived mononuclear cells isolated from 20-week-old female non-obese diabetic mice showed heterogeneity of their V/3 gene usage. In order to examine the role of T lymphocyte subsets expressing specific T-cell receptor V/3 gene segments in the development of diabetes mellitus, T-cell receptor Vfl-specific monoclona! antibodies were administered to 10-week-old male nonobese diabetic mice treated with cyclophosphamide. None of the antibodies used could significantly diminish the incidence of cyclophosphamide-induced diabetes and the severity of insulitis [anti-Vfl3 (11 of 22 mice became diabetic, 50 %), anti-V/35 (9 of 14, 64 %), anti-Vfl8 (9 of 21, 43 %), anti-V/311 (12 of 23, 52%), anti-V]314 (7 of 12,

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Author

T. Taki; K. Yokono; K. Amano; N. Hatamori; Y. Hirao; Y. Tominaga; S. Maeda; M. Kasuga

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0012-186X)

Published

1993

Language

EN

Field

Medicine (Health Sciences)