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Unrestricted recognition of class I neodeterminants generated by exon shuffling by Ulrike Horstmann; Bernd Arnold; Günter J. Hämmerling is a Immunology and Microbiology article available to read on EtoBox.

What is Unrestricted recognition of class I neodeterminants generated by exon shuffling about?

We and others have previously reported that homologous exchange of alpha 1 or alpha 2 domains between different alleles led to loss of most determinants recognized by cytotoxic T lymphocytes (CTL) raised against the parental H-2 class I antigens. Here we demonstrate that exchange of alpha 1 or alpha 2 domains between the Kk and Kd allele results in the formation of neodeterminants against which allospecific CTL can be generated in responder mice of various related and unrelated H-2 haplotypes. In fact, only CTL against the neodeterminants on the hybrid molecules were found and none against the parental Kk and Kd determinants. In addition our data show that recognition of the neodeterminants is H-2 unrestricted. These findings suggest that in the hybrid molecules the basic structure of a major histocompatibility complex molecule has been preserved although most parental allodeterminants on the alpha 1 and alpha 2 domains have been modified.

Who reads Unrestricted recognition of class I neodeterminants generated by exon shuffling?

Author

Ulrike Horstmann; Bernd Arnold; Günter J. Hämmerling

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)

Published

1986

Language

EN

Field

Immunology and Microbiology (Life Sciences)