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The Significance of Lateral Lymph Node Metastasis in Low Rectal Cancer: a Propensity Score Matching Study by Liming Wang; Yasumitsu Hirano; Gregory Heng; Toshimasa Ishii; Hiroka Kondo; Kiyoka Hara; Nao Obara; Masahiro Asari; Shigeki Yamaguchi is a Medicine article available to read on EtoBox.

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Background The indications for lateral lymph node dissection (LLND) in rectal cancer have been controversial. The purpose of this study was to clarify the significance of lateral lymph node metastasis in low rectal cancer. Methods This was a retrospective study at a high-volume cancer center in Japan. In this study, 40 patients with pathologically positive LLN (LLN+) were matched with 175 negative (LLN-) patients by propensity score matching (PSM). COX regression analysis was used to identify independent risk factors related to prognosis. The relapse-free survival rate (RFS) and overall survival rate (OS) of the 2 groups before and after matching were analyzed. Results Of the 64 patients undergoing LLND, 40 (62.5%) patients had LLN+ disease. The LLN+ patients showed deeper infiltration of the primary tumor than the LLN-patients (T3-T4: 87.5% vs. 72.0%; p = 0.044), a greater number of metastatic lymph nodes (N2: 75.0% vs. 35.4%; p < 0.001), and a higher rate of local recurrence (30% vs. 9.1%; p < 0.001). Adjuvant chemotherapy was more common in the 40 LLN+ patients than in the 175 LLN-patients (70.0% vs. 46.8%; p = 0.008). After relapse, the rate of first-line chemotherapy administr

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Author

Liming Wang; Yasumitsu Hirano; Gregory Heng; Toshimasa Ishii; Hiroka Kondo; Kiyoka Hara; Nao Obara; Masahiro Asari; Shigeki Yamaguchi

Publisher

Springer-Verlag; Springer Verlag; Elsevier BV; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc.; Springer Nature (ISSN 1091-255X)

Published

2020

Language

EN

Field

Medicine (Health Sciences)