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Bovine Oviductal Organoids: a Multi-omics Approach to Capture the Cellular and Extracellular Molecular Response of the Oviduct to Heat Stress by Nico G. Menjivar; Ahmed Gad; Riley E. Thompson; Mindy A. Meyers; Fiona K. Hollinshead; Dawit Tesfaye is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Bovine Oviductal Organoids: a Multi-omics Approach to Capture the Cellular and Extracellular Molecular Response of the Oviduct to Heat Stress about?
## Background The mammalian oviduct is a complex, fibromuscular organ known for its role in orchestrating a series of timely and dynamic changes to suitably support early embryogenesis. Climate change-induced heat stress (HS) is one of the largest single stressors compromising reproductive function in humans and farm animals via systemic changes in the redox status of the maternal environment, adversely affecting fertilization and early embryonic development. Oviductal organoids represent a unique 3-dimensional, biomimetic model to study the physiology of the oviduct and its subsequent impact on embryo development under various environmental conditions. ## Results Our study is the first to demonstrate an innovative approach to understanding the cascade of molecular changes sustained by bovine oviductal organoids under HS and the subsequent maternal signals harnessed within their secreted extracellular vesicles (EVs). Transcriptomic analysis of oviductal organoids exposed to HS revealed 2,570 differentially expressed genes (1,222 up‐ and 1,348 downregulated), while EV-coupled miRNome analysis disclosed 18 miRNAs with significant differential expression (12 up- and 6 downregulated) i
Who reads Bovine Oviductal Organoids: a Multi-omics Approach to Capture the Cellular and Extracellular Molecular Response of the Oviduct to Heat Stress?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Nico G. Menjivar; Ahmed Gad; Riley E. Thompson; Mindy A. Meyers; Fiona K. Hollinshead; Dawit Tesfaye
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)