Can I read Evaluation of Inflammatory Bowel Disease Activity in Children Using Serum Trefoil Factor Peptide on EtoBox?

Evaluation of Inflammatory Bowel Disease Activity in Children Using Serum Trefoil Factor Peptide by Xu Teng; Yuming Yang; Lu Liu; Lijuan Yang; Jie Wu; Mei Sun; Lingfen Xu is a Medicine article available to read on EtoBox.

What is Evaluation of Inflammatory Bowel Disease Activity in Children Using Serum Trefoil Factor Peptide about?

## Background: The diagnosis of ibd and evaluation of treatment require endoscopy, which is difficult in children. this study evaluated the use of tff3 as a biomarker. ## Methods: Permeability of the intestinal mucosa and serum tff3 were assayed and colon tissue was harvested 7 days after inducing ibd in mice with tnbsa. tff3 was monitored in 51 pediatric ibd patients stratified by active disease or remission and in 20 healthy children. mucosal healing was assessed by the simple endoscopic score for crohn disease and baron scores in cd and uc patients. ## Results: Histological evaluation revealed transmural inflammation of the colon in ibd model mice. permeability of the intestinal mucosa and serum tff3 were both higher in tnbsa-treated than in control mice (p < 0.05). tff3 was higher in children with active ibd than in those in remission and in healthy children (p < 0.05). tff3 was positively correlated with the ses-cd score (p < 0.05) but not with either the pediatric cdai score or the serum crp. the sensitivity of serum tff3 for monitoring cd activity was 100% and the specificity was 76.2%. ## Conclusions: Tff3 level increased with cd activity, which is of significance for diagn

Who reads Evaluation of Inflammatory Bowel Disease Activity in Children Using Serum Trefoil Factor Peptide?

Author

Xu Teng; Yuming Yang; Lu Liu; Lijuan Yang; Jie Wu; Mei Sun; Lingfen Xu

Publisher

Nature Publishing Group; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0031-3998)

Published

2020

Language

EN

Field

Medicine (Health Sciences)