Opening book details…
Can I read Endothelin Induces Functional Hypertrophy of Peritubular Smooth Muscle Cells on EtoBox?
Endothelin Induces Functional Hypertrophy of Peritubular Smooth Muscle Cells by Francesca Romano; Guido Gambara; Paola De Cesaris; Elio Ziparo; Fioretta Palombi; Antonio Filippini is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Endothelin Induces Functional Hypertrophy of Peritubular Smooth Muscle Cells about?
## Abstract When chronically stimulated with agonists of contraction, smooth muscle cells (SMCs) undergo cell hypertrophy, a process defined as increase in size and potentiation of the contractile phenotype in the absence of proliferation. Hypertrophic response has long been associated to a number of pathologies of the cardiovascular and respiratory systems. We have investigated the phenotypic and functional response of SMCs to long‐term treatment with endothelin. Our model was primary cultures of peritubular smooth muscle cells (PSMC) a testicular cell type target of locally produced endothelin and characterized by an unusual phenotypic stability when cultured in simple medium in complete absence of serum. We report the following responses of PSMC to 4‐day exposure to ET‐1: (i) increased protein synthesis without induction of cell proliferation; (ii) increase in cell size (evaluated by means of flow cytometry) and increased expression of SM‐α‐actin, desmin, caldesmon and calponin, markers of the contractile phenotype. In experiments of selective stimulation of either ETA or ETB receptor subtypes, both proved to be involved in inducing the observed hypertrophic responses. The hyper
Who reads Endothelin Induces Functional Hypertrophy of Peritubular Smooth Muscle Cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Francesca Romano; Guido Gambara; Paola De Cesaris; Elio Ziparo; Fioretta Palombi; Antonio Filippini
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)