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Interleukin-33 Is Expressed in Differentiated Osteoblasts and Blocks Osteoclast Formation from Bone Marrow Precursor Cells by Jochen Schulze; Thomas Bickert; F Timo Beil; Mario M Zaiss; Joachim Albers; Kristofer Wintges; Thomas Streichert; Kristin Klaetschke; Johannes Keller; Tim‐Nicolas Hissnauer; Alexander S Spiro; Andre Gessner; Georg Schett; Michael Amling; Andrew NJ McKenzie; Andrea Kristina Horst; Thorsten Schinke is a Medicine article available to read on EtoBox.
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## Abstract Since the hematopoetic system is located within the bone marrow, it is not surprising that recent evidence has demonstrated the existence of molecular interactions between bone and immune cells. While interleukin 1 (IL‐1) and IL‐18, two cytokines of the IL‐1 family, have been shown to regulate differentiation and activity of bone cells, the role of IL‐33, another IL‐1 family member, has not been addressed yet. Since we observed that the expression of IL‐33 increases during osteoblast differentiation, we analyzed its possible influence on bone formation and observed that IL‐33 did not affect matrix mineralization but enhanced the expression of __Tnfsf11__, the gene encoding RANKL. This finding led us to analyze the skeletal phenotype of __Il1rl1‐__deficient mice, which lack the IL‐33 receptor ST2. Unexpectedly, these mice displayed normal bone formation but increased bone resorption, thereby resulting in low trabecular bone mass. Since this finding suggested a negative influence of IL‐33 on osteoclastogenesis, we next analyzed osteoclast differentiation from bone marrow precursor cells and observed that IL‐33 completely abolished the generation of TRACP^+^ multinucleated
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- Author
- Jochen Schulze; Thomas Bickert; F Timo Beil; Mario M Zaiss; Joachim Albers; Kristofer Wintges; Thomas Streichert; Kristin Klaetschke; Johannes Keller; Tim‐Nicolas Hissnauer; Alexander S Spiro; Andre Gessner; Georg Schett; Michael Amling; Andrew NJ McKenzie; Andrea Kristina Horst; Thorsten Schinke
- Publisher
- American Society for Bone and Mineral Research; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0884-0431)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)