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Comparative Study of Dexmedetomidine and Fentanyl to Obtund the Pressure Response to Laryngoscopy and Intubation by Ajay Singh Thapa; Rajesh Kumar Yadav; Binita Dhakal is a Medicine article available to read on EtoBox.

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Introduction: Airway manipulation during endotracheal intubation is associated with hemodynamic and cardiovascular responses. Different agents have been used to obtund the pressure response. Objectives: To evaluate the place of Dexmedetomidine for routine use during induction of anesthesia to blunt pressure response to laryngoscopy and intubation. Methodology: One hundred patients of ASA I and II were randomly divided into two groups. Group A received Midazolam (0.05 mg/kg) a n d Fentanyl (2 mcg/Kg) and group B received Dexmedetomidine (0.6 mcg/kg) 10 minutes before induction of anesthesia. Both groups were induced with Propofol (1.5 mg/Kg). In all patients after induction (loss of eye lashes reflex) tracheal intubation was facilitated using Rocuronium 1mg/kg. Baseline heart rate was noted and hemodynamic response to intubation was observed 3, 6 and 9 minutes after intubation. Results: In group A, time for loss of eyelashes reflex was 17.45±2.19 seconds and in group B it was 11.33±2.64 seconds. In group A, after intubation heart rate increased by 11.22±2.37, 5.71±1.68, 2.34±1.73 in3, 6 and 9 minutes respectively. In group A, after intubation MAP increased by 6.49±1.37, 3.30±1.15, a

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Author

Ajay Singh Thapa; Rajesh Kumar Yadav; Binita Dhakal

Publisher

Nepal Journals Online; Biratnagar: Birat Medical College & Teaching Hospital; Nepal Journals Online (JOL) (ISSN 2542-2758)

Published

2019

Language

EN

Field

Medicine (Health Sciences)