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PI3K/AKT/p53 pathway inhibits infectious spleen and kidney necrosis virus infection by regulating autophagy and immune responses by Xiaoting Zhang,Yue Ming,Xiaozhe Fu,Yinjie Niu,Qiang Lin,Hongru Liang,Xia Luo,Lihui Liu,Ningqiu Li is a nonfiction available to read on EtoBox.

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Fish and Shellfish Immunology, 120 (2022) 648-657. doi:10.1016/j.fsi.2021.12.046 PI3K/AKT/p53 pathway inhibits infectious spleen and kidney necrosis virus infection by regulating autophagy and immune resp ... 1 1 Introduction 1 2 Materials and methods 2 2.1 Cells and virus strains 2 2.2 Antibodies and pharmaceuticals 2 2.3 siRNA stimulation for gene knockdown 2 2.4 Compound treatments and virus infection 2 2.5 RNA extraction and gene expression analysis 2 2.6 Western blotting 2 2.7 Statistical analysis 3 3 Results 3 3.1 ISKNV infection activates PI3K/AKT/p53/mTOR pathway while inhibits autophagy in CPB cells 3 3.2 Regulations of PI3K on autophagy and ISKNV replication 3 3.3 Regulations of AKT on autophagy and ISKNV replication 3 3.4 Regulations of p53 on autophagy and ISKNV replication 4 3.5 The PI3K/AKT/p53 pathway promotes immune-related genes in ISKNV-infected CPB cells 4 4 Discussion 4 CRediT authorship contribution statement 8 Acknowledgments 8 References 8 ISKNV,PI3K/AKT/p53,Autophagy,Antiviral target,Siniperca chuatsi

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Author

Xiaoting Zhang,Yue Ming,Xiaozhe Fu,Yinjie Niu,Qiang Lin,Hongru Liang,Xia Luo,Lihui Liu,Ningqiu Li

Publisher

Elsevier Ltd

Language

EN

Category

nonfiction