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Glomerular Lipidosis as a Feature of Renal-limited Macrophage Activation Syndrome in a Transplanted Kidney: a Case Report by Kentaro Sugisaki; Takahiro Uchida; Sachiko Iwama; Masaaki Okihara; Isao Akashi; Yu Kihara; Osamu Konno; Masayuki Kuroda; Junki Koike; Hitoshi Iwamoto; Takashi Oda is a Medicine article available to read on EtoBox.

What is Glomerular Lipidosis as a Feature of Renal-limited Macrophage Activation Syndrome in a Transplanted Kidney: a Case Report about?

## Background Glomerular lipidosis is a rare histological feature presenting the extensive glomerular accumulation of lipids with or without histiocytic infiltration, which develops under various conditions. Among its various etiologies, macrophage activation syndrome (MAS) is a condition reported to be associated with histiocytic glomerular lipidosis. Here we describe the first case of glomerular lipidosis observed in a renal allograft that histologically mimicked histiocytic glomerulopathy owing to MAS. ## Case presentation A 42-year-old man underwent successful living-donor kidney transplantation. However, middle-grade proteinuria and increased serum triglyceride levels indicative of type V hyperlipidemia developed rapidly thereafter. An allograft biopsy performed 6 months after the transplantation showed extensive glomerular infiltration of CD68^+^ foam cells (histiocytes) intermingled with many CD3^+^ T-cells (predominantly CD8^+^ cells). Furthermore, frequent contact between glomerular T-cells and histiocytes, and the existence of activated CD8^+^ cells (CD8^+^, HLA-DR^+^ cells) were observed by double immunostaining. There was no clinicopathological data suggesting lipoprote

Who reads Glomerular Lipidosis as a Feature of Renal-limited Macrophage Activation Syndrome in a Transplanted Kidney: a Case Report?

Author

Kentaro Sugisaki; Takahiro Uchida; Sachiko Iwama; Masaaki Okihara; Isao Akashi; Yu Kihara; Osamu Konno; Masayuki Kuroda; Junki Koike; Hitoshi Iwamoto; Takashi Oda

Publisher

Springer Science and Business Media LLC

Published

2023

Field

Medicine (Health Sciences)