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What is Synthesis of Darunavir via Glycolate Aldol about?

This article presents a diastereoselective synthesis of the HIV protease inhibitor darunavir and its derivatives using a titanium tetrachloride-mediated asymmetric glycolate aldol addition reaction. The synthesis involves several steps including transamidation, reduction, and bis-nosylation to introduce various functional groups, ultimately yielding darunavir and related compounds. The developed synthetic pathway aims to enhance the potency and efficacy of darunavir against resistant HIV variants.

Author

asiakazmierczak460

Language

EN