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Improved correlation to quantitative DCE‐MRI pharmacokinetic parameters using a modified initial area under the uptake curve (mIAUC) approach by Hai‐Ling Margaret Cheng is a Medicine article available to read on EtoBox.

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## Abstract ## Purpose To propose a modified initial area under the uptake curve (mIAUC) dynamic contrast‐enhanced (DCE)‐MRI approach to achieve better distinction of underlying physiology. ## Materials and Methods The mIAUC is formulated on common characteristics of tissue contrast uptake curves observed over a wide range of physiological conditions. The new metrics, IAUC~__Ktrans__~ and IAUC~__ve__~, are related to the transfer constant (__K__^trans^) and interstitial volume (__v__~e~), respectively. Tissue uptake curves were simulated over a range of physiological values and analyzed using the proposed mIAUC, conventional IAUC, and Tofts' pharmacokinetic model. ## Results IAUC~__Ktrans__~ and IAUC~__ve__~ are highly correlated to the true __K__^trans^ and __v__~e~ (ρ = 0.97 and 0.95, respectively), approaching the performance of Tofts' model based on a 1.5‐s sampled arterial input function (AIF) (ρ = 0.98 and 0.98) under noise conditions typical in DCE‐MRI experiments. Lower correlations were obtained with conventional IAUC~60~ and IAUC~120~ (ρ = 0.82 and 0.61) and Tofts' parameters fitted using a biexponential AIF (ρ = 0.81 and 0.90). ## Conclusion The proposed mIAUC approach r

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Author

Hai‐Ling Margaret Cheng

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)

Published

2009

Language

EN

Field

Medicine (Health Sciences)