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Can I read Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice on EtoBox?
Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice by Matthew T. Birnie; Annabel K. Short; Gregory B. de Carvalho; Lara Taniguchi; Benjamin G. Gunn; Aidan L. Pham; Christy A. Itoga; Xiangmin Xu; Lulu Y. Chen; Stephen V. Mahler; Yuncai Chen; Tallie Z. Baram is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice about?
## Abstract Disrupted operations of the reward circuit underlie major emotional disorders, including depression, which commonly arise following early life stress / adversity (ELA). However, how ELA enduringly impacts reward circuit functions remains unclear. We characterize a stress-sensitive projection connecting basolateral amygdala (BLA) and nucleus accumbens (NAc) that co-expresses GABA and the stress-reactive neuropeptide corticotropin-releasing hormone (CRH). We identify a crucial role for this projection in executing disrupted reward behaviors provoked by ELA: chemogenetic and optogenetic stimulation of the projection in control male mice suppresses several reward behaviors, recapitulating deficits resulting from ELA and demonstrating the pathway’s contributions to normal reward behaviors. In adult ELA mice, inhibiting–but not stimulating–the projection, restores typical reward behaviors yet has little effect in controls, indicating ELA-induced maladaptive plasticity of this reward-circuit component. Thus, we discover a stress-sensitive, reward inhibiting BLA → NAc projection with unique molecular features, which may provide intervention targets for disabling mental illnesse
Who reads Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Matthew T. Birnie; Annabel K. Short; Gregory B. de Carvalho; Lara Taniguchi; Benjamin G. Gunn; Aidan L. Pham; Christy A. Itoga; Xiangmin Xu; Lulu Y. Chen; Stephen V. Mahler; Yuncai Chen; Tallie Z. Baram
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)