About this Medicine article

Red Grape Seed Extract Improves Lipid Profiles and Decreases Oxidized Low-Density Lipoprotein in Patients with Mild Hyperlipidemia by Seyed-Mostafa Razavi; Sharareh Gholamin; Ali Eskandari; Nakta Mohsenian; Amir Ghorbanihaghjo; Abbas Delazar; Nadereh Rashtchizadeh; Maryam Keshtkar-Jahromi; Hassan Argani is a Medicine article available to read on EtoBox.

Hyperlipidemia can lead to atherosclerosis by lipoprotein deposition inside the vessel wall and oxidative stress induction that leads to the formation of atherosclerotic plaque. Oxidized low-density lipoprotein particles (Ox-LDL) have a key role in the pathogenesis of atherosclerosis. The lipid-lowering properties and antioxidants of the grape seed can be beneficial in atherosclerosis prevention. We conducted a randomized double-blind placebo-controlled crossover clinical trial. Fifty-two mildly hyperlipidemic individuals were divided into two groups that received either 200 mg/day of the red grape seed extract (RGSE) or placebo for 8 weeks. After an 8-week washout period, the groups were crossed over for another 8 weeks. Lipid profiles and Ox-LDL were measured at the beginning and the end of each phase. RGSE consumption reduced total cholesterol (-10.68 -26.76 mg/dL, P = .015), LDL cholesterol (-9.66 -23.92 mg/dL, P = .014), and Ox-LDL (-5.47 -12.12 mg/dL, P = .008). While triglyceride and very low-density lipoprotein cholesterol were decreased and high-density lipoprotein cholesterol was increased by RGSE, the changes were not statistically significant. RGSE consumption decreases

Author

Seyed-Mostafa Razavi; Sharareh Gholamin; Ali Eskandari; Nakta Mohsenian; Amir Ghorbanihaghjo; Abbas Delazar; Nadereh Rashtchizadeh; Maryam Keshtkar-Jahromi; Hassan Argani

Publisher

Mary Ann Liebert Inc

Published

2013

Language

EN

Field

Medicine (Health Sciences)