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Blood Pressure Affects the Early CT Perfusion Imaging in Patients with aSAH Reflecting Early Disturbed Autoregulation by Björn B. Hofmann; Daniel M. Donaldson; Igor Fischer; Cihat Karadag; Milad Neyazi; Guilherme S. Piedade; Yousef Abusabha; Sajjad Muhammad; Christian Rubbert; Daniel Hänggi; Kerim Beseoglu is a Medicine article available to read on EtoBox.
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## Background Early computed tomography perfusion (CTP) is frequently used to predict delayed cerebral ischemia following aneurysmatic subarachnoid hemorrhage (aSAH). However, the influence of blood pressure on CTP is currently controversial (HIMALAIA trial), which differs from our clinical observations. Therefore, we aimed to investigate the influence of blood pressure on early CTP imaging in patients with aSAH. ## Methods We retrospectively analyzed the mean transit time (MTT) of early CTP imaging within 24 h after bleeding prior to aneurysm occlusion with respect to blood pressure shortly before or after the examination in 134 patients. We correlated the cerebral blood flow with the cerebral perfusion pressure in the case of patients with intracranial pressure measurement. We performed a subgroup analysis of good-grade (World Federation of Neurosurgical Societies [WFNS] I–III), poor-grade (WFNS IV–V), and solely WFNS grade V aSAH patients. ## Results Mean arterial pressure (MAP) significantly correlated inversely with the mean MTT in early CTP imaging (__R__ = − 0.18, 95% confidence interval [CI] − 0.34 to − 0.01, __p__ = 0.042). Lower mean blood pressure was significantly asso
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- Author
- Björn B. Hofmann; Daniel M. Donaldson; Igor Fischer; Cihat Karadag; Milad Neyazi; Guilherme S. Piedade; Yousef Abusabha; Sajjad Muhammad; Christian Rubbert; Daniel Hänggi; Kerim Beseoglu
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)