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Adult-Onset Still’s Disease—A Complex Disease, a Challenging Treatment by Luana Andreea Macovei; Alexandra Burlui; Ioana Bratoiu; Ciprian Rezus; Anca Cardoneanu; Patricia Richter; Andreea Szalontay; Elena Rezus is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Adult-Onset Still’s Disease—A Complex Disease, a Challenging Treatment about?

Adult-onset Still’s disease (AOSD) is a systemic inflammatory disorder with an unknown cause characterized by high-spiking fever, lymphadenopathy, hepatosplenomegaly, hyperferritinemia, and leukocytosis. The clinical course can be divided into three significant patterns, each with a different prognosis: Self-limited or monophasic, intermittent or polycyclic systemic, and chronic articular. Two criteria sets have been validated. The Yamaguchi criteria are the most generally used, although the Fautrel criteria offer the benefit of adding ferritin and glycosylated ferritin values. AOSD’s pathogenesis is not yet completely understood. Chemokines and pro-inflammatory cytokines, including interferon (IFN)-γ, tumor necrosis factor α (TNFα), interleukin (IL)-1, IL-6, IL-8, and IL-18, play a crucial role in the progression of illness, resulting in the development of innovative targeted therapeutics. There are no treatment guidelines for AOSD due to its rarity, absence of controlled research, and lack of a standard definition for remission and therapy objectives. Non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids (CS), and conventional synthetic disease-modifying antirheumatic d

Who reads Adult-Onset Still’s Disease—A Complex Disease, a Challenging Treatment?

Author

Luana Andreea Macovei; Alexandra Burlui; Ioana Bratoiu; Ciprian Rezus; Anca Cardoneanu; Patricia Richter; Andreea Szalontay; Elena Rezus

Publisher

MDPI AG

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)