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A case of Parkinson's disease exacerbated by fluoxetine by Guy Chouinard; Sarah Sultan is a Medicine article available to read on EtoBox.

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## Abstract Fluoxetine (Prozac®) is a potent serotonin (5‐HT) reuptake inhibitor which has rapidly gained popularity as a first‐line antidepressant due to its favourable side‐effect profile. However, it has recently been reported to worsen drug‐induced parkinsonism when used in conjunction with neuroleptics (Bouchard __et al.__, 1989; Tate, 1989; Brod, 1989). Since fluoxetine inhibits hepatic microsomal enzymes, a pharmacokinetic interaction cannot be ruled out in such cases — the drug is known to interact with other psychotropic drugs such as MAO inhibitors (Sternbach, 1988; Feighner __et al.__, 1990) and tricyclic antidepressants (Bell and Cole, 1988; Vaughan, 1988; Goodnick, 1989; Schraml __et al.__, 1989; Kahn, 1990) via this mechanism among others. So far, fluoxetine has not been reported to worsen symptoms in patients with Parkinson's disease (PD) who have never received neuroleptics. Bouchard __et al.__ (1989) observed that other selective 5‐HT reuptake inhibitors might exacerbate PD, and Meltzer __et al.__ (1979) described a bipolar patient who developed an acute dystonic reaction, with parkinsonian rigidity and increased serum prolactin when treated with fluoxetine for psy

Who reads A case of Parkinson's disease exacerbated by fluoxetine?

Author

Guy Chouinard; Sarah Sultan

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-6222)

Published

1992

Language

EN

Field

Medicine (Health Sciences)