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Can I read The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction on EtoBox?
The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction by Liu, Hilary Y. (author);Gale, Jenna R. (author);Reynolds, Ian J. (author);Weiss, John H. (author);Aizenman, Elias (author) is a Medicine article available to read on EtoBox.
What is The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction about?
Zinc is a highly abundant cation in the brain, essential for cellular functions, including transcription, enzymatic activity, and cell signaling. However, zinc can also trigger injurious cascades in neurons, contributing to the pathology of neurodegenerative diseases. Mitochondria, critical for meeting the high energy demands of the central nervous system (CNS), are a principal target of the deleterious actions of zinc. An increasing body of work suggests that intracellular zinc can, under certain circumstances, contribute to neuronal damage by inhibiting mitochondrial energy processes, including dissipation of the mitochondrial membrane potential (MMP), leading to ATP depletion. Additional consequences of zinc-mediated mitochondrial damage include reactive oxygen species (ROS) generation, mitochondrial permeability transition, and excitotoxic calcium deregulation. Zinc can also induce mitochondrial fission, resulting in mitochondrial fragmentation, as well as inhibition of mitochondrial motility. Here, we review the known mechanisms responsible for the deleterious actions of zinc on the organelle, within the context of neuronal injury associated with neurodegenerative processes. E
Who reads The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Liu, Hilary Y. (author);Gale, Jenna R. (author);Reynolds, Ian J. (author);Weiss, John H. (author);Aizenman, Elias (author)
- Publisher
- MDPI AG
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)