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Chimeric antigen receptor T-cell therapy for melanoma by Azadehsadat Razavi; Mahsa Keshavarz-Fathi; John Pawelek; Nima Rezaei is a Medicine article available to read on EtoBox.

What is Chimeric antigen receptor T-cell therapy for melanoma about?

## Introduction: In recent years, chimeric antigen receptor (CAR) T cell therapy has emerged as a cancer treatment. After initial therapeutic success for hematologic malignancies, this approach has been extended for the treatment of solid tumors including melanoma. Areas covered: T cells need to be reprogramed to recognize specific antigens expressed only in tumor cells, a difficult problem since cancer cells are simply transformed normal cells. Tumor antigens, namely, CSPG4, CD70, and GD2 have been targeted by CAR-T cells for melanoma. Moreover, different costimulatory signaling domains need to be selected to direct T cell fate. In this review, various approaches for the treatment of melanoma and their effectiveness are comprehensively reviewed and the current status, challenges, and future perspective of CAR-T cell therapy for melanoma are discussed. Literature search was accomplished in three databases (PubMed, Google scholar, and Clinicaltrials.gov). Published papers and clinical trials were screened and relevant documents were included by checking pre-defined eligibility criteria. Expert opinion: Despite obstacles and the risk of adverse events, CAR T cell therapy could be use

Who reads Chimeric antigen receptor T-cell therapy for melanoma?

Author

Azadehsadat Razavi; Mahsa Keshavarz-Fathi; John Pawelek; Nima Rezaei

Publisher

Informa UK Limited

Published

2021

Language

EN

Field

Medicine (Health Sciences)