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Handbook of Biomarkers and Precision Medicine by Carini, Claudio;Fidock, Mark;Gool, Alain van; is a book available to read on EtoBox.
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Cover 1 Half Title 2 Title Page 4 Copyright Page 5 Dedication 6 Table of Contents 8 Preface 14 About the Editors 16 Contributors 18 1: What Is a Biomarker and Its Role in Drug Development? 28 1.1 Definitions and Conceptual Framework of Biomarkers in Precision Medicine 29 1.2 In Search of Predictive Biomarkers in Cancer Immunotherapy: Establishment of Collaborative Networks for the Validation Process 35 1.3 Integrating Personalized Medicine in the Health Care: Payers and Reimbursements 46 1.4 Regulatory Strategies to Accelerate the Implementation of Biomarkers and Companion Diagnostics 54 2: Biomarkers in Preclinical Sciences 62 2.1 Lost in Translation: The Challenges with the Use of Animal Models in Translational Research 63 2.2 Application of Pharmacokinetic and Pharmacodynamic Modeling of Biomarkers of Efficacy in Translational Research 71 2.3 The DIAMONDS Platform: Providing Decision Support for Toxicological Assessment Based on Integration of Structural, Toxicological and Biomarker Information 91 2.4 Predicting the Safety of Drug Targets: An In Silico Perspective 101 2.5 Unwanted Immunogenicity Responses to Biotherapeutics 114 2.6 Biomarker Use for Advanced Screening of Drug-In
- Author
- Carini, Claudio;Fidock, Mark;Gool, Alain van;
- Language
- EN
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