Opening book details…
Can I read Facilitation of α-Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Transmission in the Suprachiasmatic Nucleus by Aniracetam Enhances Photic Responses of the Biological Clock in Rodents on EtoBox?
Facilitation of α-Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Transmission in the Suprachiasmatic Nucleus by Aniracetam Enhances Photic Responses of the Biological Clock in Rodents by Takahiro Moriya; Masayuki Ikeda; Koji Teshima; Reiko Hara; Koji Kuriyama; Tohru Yoshioka; Charles N. Allen; Shigenobu Shibata is a Neuroscience article available to read on EtoBox.
What is Facilitation of α-Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Transmission in the Suprachiasmatic Nucleus by Aniracetam Enhances Photic Responses of the Biological Clock in Rodents about?
## Abstract This study was designed to test whether the α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate (AMPA) receptor‐facilitating drug, aniracetam, could potentiate photic responses of the biological clock in the suprachiasmatic nucleus (SCN) of rodents. Using the whole‐cell patch technique, we first demonstrated that AMPA currents elicited by either local AMPA application or optic chiasm stimulation were augmented by aniracetam in the neurons of the SCN. The AMPA application‐elicited increase of intracellular Ca^2+^ concentration in SCN slices was also enhanced by aniracetam treatment. The systemic injection of aniracetam dose‐dependently (10–100 mg/kg) potentiated the phase delay in behavioral rhythm induced by brief light exposure of low intensity (3 lux) but not high intensity (10 or 60 lux) during early subjective night. Under the blockade of NMDA receptors by (+) MK801, aniracetam failed to potentiate a light (3 lux)‐induced phase delay in behavioral rhythm. Aniracetam increased the photic induction of c‐Fos protein in the SCN that was elicited by low intensity light exposure (3 lux). These results suggest that AMPA receptor‐mediated responses facilitated by aniracetam ca
Who reads Facilitation of α-Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Transmission in the Suprachiasmatic Nucleus by Aniracetam Enhances Photic Responses of the Biological Clock in Rodents?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Takahiro Moriya; Masayuki Ikeda; Koji Teshima; Reiko Hara; Koji Kuriyama; Tohru Yoshioka; Charles N. Allen; Shigenobu Shibata
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 2003
- Language
- EN
- Field
- Neuroscience (Life Sciences)