Opening book details…
Can I read Enhancement of Biliary Carcinogenesis in Hamsters by Cholecystokinin on EtoBox?
Enhancement of Biliary Carcinogenesis in Hamsters by Cholecystokinin by Yoshito Ikematsu; Tsutomu Tomioka; Yoshitsugu Tajima; Tsukasa Tsunoda; Takashi Kanematsu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Enhancement of Biliary Carcinogenesis in Hamsters by Cholecystokinin about?
We recently developed a new model for rapid and reproducible induction of biliary carcinoma in hamsters. In the present study, we evaluated the effects of cholecystokinin (CCK), which has a trophic action on the gastrointestinal tract and on the pancreaticobiliary system, on biliary carcinogenesis in this hamster model. Hamsters treated with N-nitrosobis (2-oxopropyl) amine (BOP) were divided into four groups: In Group I, hydrolyzed gelatin, a solvent of CCK, was injected subcutaneously. In Groups II and III, CCK 2.5 and 25 microgram/kg were administered, respectively. In Group IV loxiglumide, a CCK receptor antagonist, was administered. CCK significantly promoted the carcinogenetic effect of BOP in the intra- and extrahepatic bile ducts but not in the gallbladder or pancreas. Loxiglumide exerted an inhibitory effect on carcinogenesis in the intrahepatic bile duct.
Who reads Enhancement of Biliary Carcinogenesis in Hamsters by Cholecystokinin?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yoshito Ikematsu; Tsutomu Tomioka; Yoshitsugu Tajima; Tsukasa Tsunoda; Takashi Kanematsu
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0364-2313)
- Published
- 1995
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Physical Sciences)