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Corneal Confocal Microscopy Detects Small Nerve Fibre Damage in Patients with Painful Diabetic Neuropathy by Kalteniece, Alise; Ferdousi, Maryam; Azmi, Shazli; Mubita, Womba M.; Marshall, Andrew; Lauria, Giuseppe; Faber, Catharina G.; Soran, Handrean; Malik, Rayaz A. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Corneal Confocal Microscopy Detects Small Nerve Fibre Damage in Patients with Painful Diabetic Neuropathy about?
Neuropathic pain is believed to arise from damage to nociceptive C fibres in diabetic neuropathy (DN). We have utilised corneal confocal microscopy (CCM) to quantify the severity of small nerve fibre damage in relation to the severity of neuropathic pain and quality of life (QoL) in patients with and without painful DN. 30 controls and patients with painful (n = 78) and painless (n = 62) DN underwent assessment of large and small nerve fibre function, CCM, neuropathic symptoms (small fibre neuropathy symptom inventory questionnaire, neuropathic pain scale) and QoL (SF-36, pre-R-ODS and hospital anxiety and depression scale). Patients with painful compared to painless DN, had comparable neurophysiology and vibration perception, but lower corneal nerve fibre density (20.1 ± 0.87 vs. 24.13 ± 0.91, P = 0.005), branch density (44.4 ± 3.31 vs. 57.74 ± 3.98, P = 0.03), length (19.61 ± 0.81 vs. 22.77 ± 0.83, P = 0.01), inferior whorl length (18.03 ± 1.46 vs. 25.1 ± 1.95, P = 0.005) and cold sensation threshold (21.35 ± 0.99 vs. 26.08 ± 0.5, P < 0.0001) and higher warm sensation threshold (43.7 ± 0.49 vs. 41.37 ± 0.51, P = 0.004) indicative of small fibre damage. There was a significant ass
Who reads Corneal Confocal Microscopy Detects Small Nerve Fibre Damage in Patients with Painful Diabetic Neuropathy?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kalteniece, Alise; Ferdousi, Maryam; Azmi, Shazli; Mubita, Womba M.; Marshall, Andrew; Lauria, Giuseppe; Faber, Catharina G.; Soran, Handrean; Malik, Rayaz A.
- Publisher
- Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)
- Published
- 2020
- Language
- EN
- ISBN
- 9784159802067
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)