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Can I read Synthesis of Chiral Hydroxylated Cyclopentanones and Cyclopentanes on EtoBox?
Synthesis of Chiral Hydroxylated Cyclopentanones and Cyclopentanes by Allan Niidu; Anne Paju; Margus Eek; Aleksander-Mati Müürisepp; Tõnis Pehk; Margus Lopp is a Chemistry article available to read on EtoBox.
What is Synthesis of Chiral Hydroxylated Cyclopentanones and Cyclopentanes about?
A method for the synthesis of enantiomeric 1,3-dihydroxy and 2,3-dihydroxy cyclopentanones, starting from a commercially available 3-methyl-cyclopentane-1,2-dione 1, is described. Dione 1 was subjected to asymmetric 3-hydroxylation to afford 3-methyl-3hydroxy-1,2-dione 2. The carbonyl groups in 2 were selectively differentiated by converting them either in dimethylacetal 5 or acetonide 6. Stereoselective reduction of those acetals by using NaBH 4 afforded chiral methyl 1,2-dihydroxy cyclopentanone 9 and 1,3-dihydroxy cyclopentanone 10, respectively. The diols obtained were further converted to the corresponding diastereomeric triols 11-13 by hydride reduction.
Who reads Synthesis of Chiral Hydroxylated Cyclopentanones and Cyclopentanes?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Allan Niidu; Anne Paju; Margus Eek; Aleksander-Mati Müürisepp; Tõnis Pehk; Margus Lopp
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0957-4166)
- Published
- 2006
- Language
- EN
- Field
- Chemistry (Physical Sciences)