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2003-Jbc-Phosphorylation of A Pest Sequence in ABCA1 Promotes Calpain Degradation and Is Reversed by ApoA-I by 292902698 is a document available to read on EtoBox.
What is 2003-Jbc-Phosphorylation of A Pest Sequence in ABCA1 Promotes Calpain Degradation and Is Reversed by ApoA-I about?
The study investigates the phosphorylation of the PEST sequence in ABCA1 and its role in calpain-mediated degradation, revealing that phosphorylation is reduced by apoA-I interaction. Mutations in the PEST sequence lead to increased ABCA1 stability and cholesterol efflux, suggesting that dephosphorylation by apoA-I inhibits degradation. The findings highlight the regulatory mechanism of ABCA1 expression and its implications in cholesterol metabolism and atherosclerosis.
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- 292902698
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- EN