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Can I read Abnormalities in Spinal Cord Ultrastructure in a Rat Model of Post-traumatic Syringomyelia on EtoBox?
Abnormalities in Spinal Cord Ultrastructure in a Rat Model of Post-traumatic Syringomyelia by Berliner, Joel; Hemley, Sarah; Najafi, Elmira; Bilston, Lynne; Stoodley, Marcus; Lam, Magdalena is a Neuroscience article available to read on EtoBox.
What is Abnormalities in Spinal Cord Ultrastructure in a Rat Model of Post-traumatic Syringomyelia about?
## Background Syringomyelia is a serious complication of spinal cord trauma, occurring in approximately 28% of spinal cord injuries. Treatment options are limited and often produce unsatisfactory results. Post-traumatic syringomyelia (PTS) is presumably related to abnormalities of cerebrospinal fluid (CSF) and interstitial fluid hydrodynamics, but the exact mechanisms are unknown. ## Methods Transmission electron microscopy (TEM) was used to investigate in detail the interfaces between fluid and tissue in the spinal cords of healthy Sprague–Dawley rats (n = 3) and in a rat model of PTS (n = 3). PTS was induced by computer-controlled impact (75 kDyn) to the spinal cord between C6 and C8, followed by a subarachnoid injection of kaolin to produce focal arachnoiditis. Control animals received a laminectomy only to C6 and C7 vertebrae. Animals were sacrificed 12 weeks post-surgery, and spinal cords were prepared for TEM. Ultra-thin spinal cord sections at the level of the injury were counterstained for structural anatomy. ## Results Spinal cords from animals with PTS displayed several abnormalities including enlarged perivascular spaces, extracellular edema, cell death and loss of tissu
Who reads Abnormalities in Spinal Cord Ultrastructure in a Rat Model of Post-traumatic Syringomyelia?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Berliner, Joel; Hemley, Sarah; Najafi, Elmira; Bilston, Lynne; Stoodley, Marcus; Lam, Magdalena
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central; Springer Science and Business Media LLC; Springer Nature (ISSN 2045-8118)
- Published
- 2020
- Language
- EN
- Field
- Neuroscience (Life Sciences)